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Continuous GLP-1RA use for three years was associated with the greatest reduction in MACE risk compared with sulfonylureas, whereas interruptions and discontinuations were associated with a progressive attenuation of this protective effect, with risk estimates in some scenarios approaching those of the comparator group

According to a press release from Lilly (the maker of Foundayo), orforglipron will cost around $25 per month with commercial insurance and a drug savings card