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First large, head-to-head real-world comparison of tirzepatide vs semaglutide in MASLD + T2DM + obesity, ~14k per cohort, followed up to 2 years, using a new-user, active-comparator, 1:1 propensity-matched design

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This release leads to increased vascular permeability, plasma protein extravasation, white blood cell infiltration, vasodilation, mast cell breakdown, stimulation of meningeal pain receptors, and further release of inflammatory substances (10)

AlmandozJPWaddenTATewksburyCApovianCMFitchAArdJDet al

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