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Atherosclerosis is associated with impairment of vascular endothelial function, thereby compromising vasodilation and normal blood flow
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It also suppressed the production of proteins linked to apoptosis, such as p-JNK, C/EBP homologous protein, and BCL2-associated X/B-cell lymphoma-2 (Dong et al., 2021)
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Permanent opening of the mPTP results in mitochondrial depolarization, inhibition of respiration, cessation of ATP synthesis, mobilization of cytochrome C, and apoptosis 43
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