This is not surprising considering that type-2 diabetes is a risk factor for both major and mild CI [2]
Because the GLP-1 targets gut hormones that slow gastric emptying and areas of the brain associated with hunger a one-two punch that tamps down appetite
E11 is only the default when no other cause is documented
doi: 10.1002/dmrr.1080 134 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al
In db/db mice, A 1-42 -treated mice or hTauP301L mice, liraglutide alleviated tau hyperphosphorylation, and prevented dysregulation of Akt and GSK-3 in brain (161, 163, 164)
This seminal work suggested that GIPR signaling, when combined with GLP-1R signaling, plays a crucial and synergistic role in regulating energy balance, forcing a scientific re-evaluation of GIP's function