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Food and Drug Administration (FDA) for the diagnosis, treatment, cure, or prevention of any disease

Means effective dosing depends on baseline receptor density, systemic clearance rates, and whether the goal is acute enhancement or long-term structural remodeling

People with autoimmune disorders (especially thyroid disorders such as Hashimotos thyroiditis and Graves disease) Type 1 diabetes, vitiligo, lupus, Addisons disease, ulcerative colitis, infertility, acquired agammaglobulinemia, or a family history of these disorders

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In addition, people that avoid animal products can be deficient in B12