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Hypoxia-inducible factor 1 (hif-1)-mediated hypoxia increases bace1 expression and -amyloid generation

Additionally, impaired insulin signaling pathways (e.g., PI3K-AKT) disrupt GLUT4 membrane trafficking, further aggravating glucose metabolism in muscle cells and perpetuating a vicious cycle (63, 64)

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Semi-quantitative analysis was performed for five fields per section in high-power fields at 400 magnification using ImageJ software version 64 (National Institutes of Health)