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Cell Metabolism , 21(3), 443-454

iPSC-based models have demonstrated a potential mechanism for the genetic susceptibility of APOE4 for cerebral amyloid angiopathy (CAA) associated with Alzheimer's disease (Blanchard et al., 2019)

PMID: 36835987

This cytoplasmic retention prevents YAP/TAZ from entering the nucleus and engaging in transcriptional activation of genes associated with cell proliferation and survival, thereby inhibiting cardiomyocyte growth and proliferation under non-stress conditions (167, 168)

Biotin is an essential nutrient during pregnancy, as it plays roles in fetal development (including fatty acid synthesis and energy metabolism), but it should be used cautiously and only in recommended amounts during pregnancy

However, the implications of thymus overstimulation are not well understood and require further research [13]