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Any receptor that is stimulated continuously tends to become less responsive over time it down-regulates

DOI: 10.1113/jphysiol.1934.sp003147 Gericke A et al (2011): Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice

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Electrolyte supplementation helps maintain mineral balance, especially during initial phases when GI symptoms are more pronounced

doi: 10.1016/s0002-9378(40)91238-8 12 SampsonJA