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The most serious potential side effect of rituximab is progressive multifocal leukoencephalopathy (PML), an infection of the brain, which can manifest in a number of ways including trouble with gait, speech and memory

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Both agents influence insulin secretion and metabolic hormones, but through different routes: one slows gastric emptying and reduces hunger through the GLP-1 pathway, while HCG is proposed to affect metabolic rate through separate endocrine mechanisms