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When creatine is combined with resistance exercise, muscle insulin-like growth factor (IGF-1) levels increase contributing to muscle mass gain

Caution is advised in patients with Leber optic atrophy, a genetic disorder caused by chronic cyanide intoxication (such as from smoking, alcohol or some plants), against the use of cyano-B12 due to its cyanide moiety, whilst hydroxo-B12 is a cyanide antagonist and can therefore be used in these patients

A therapeutic strategy focused on metabolic vulnerabilities and nutrient addiction: the PPP metabolism

combination data is nonexistent Safety first Overlapping side effect profiles create legitimate concerns about additive adverse events Patience pays Phase 3 trials for both compounds are ongoing