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Potterf SB, Virador V, Wakamatsu K, et al

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Activation of IR and IGF1R by their cognate ligands initiates a cascade of phosphorylation events beginning with a conformational change of the receptors leading to autophosphorylation and the recruitment and phosphorylation of substrates such as IRS-1 and Shc proteins (46)

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These findings have led to ongoing clinical trials investigating GLP-1-based therapies for alcohol use disorder and other substance use conditions

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