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News about its misuse and the resulting shortages preventing access to those who need it has caused GLP-1 manufacturers to ask healthcare providers to refrain from prescribing the drug to new patients

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doi: 10.1002/mds.29500 93 PeiM.-Q.XuL.-M.YangY.-S.ChenW.-C.ChenX.-L.FangY.-M.et al

Doubling to 1000mg doesn't compensate for the missed methyl donor window