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The limited effectiveness of lifestyle changes alone increases the need for effective, long-term treatment for those with a body mass index (BMI) greater than 30 kg per m 2 or BMI of 27 kg per m 2 or greater with associated complications (e.g., hypertension, diabetes mellitus, and hyperlipidemia)

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However, document any ongoing side effects carefully, as they may be relevant to your claim

Dombrowski SU, Knittle K, Avenell A, ArajoSoares V, Sniehotta FF

The STEP 5 trial revealed that most participants, particularly adults with obesity or excess mass, achieved considerable and sustained reductions over a 104-week period

This is slightly lower than the reductions reported in RCTs, where HbA1c decreases ranged from -0.5% to -1.8% (ETD of -0.3% to -1.5%), depending on the trial and semaglutide dosage (e.g., STEP, SUSTAIN 5)