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Scenarios (e.g., unrestricted vs

In the anabolic-potency studies from Ballard and colleagues, IGF analogs that bind poorly to IGFBPs (including Long R3 IGF-1) were repeatedly more potent than native IGF-1 on a per-dose basis, precisely because more of the administered molecule remained available to receptors

Similarly, AdipoR2 deletion results in decreased PPAR- signaling pathway activity and IR

The mechanisms underlying these effects are likely multifactorial

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Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult