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Semaglutide is a potent, long-acting GLP-1RA approved for the treatment of T2D (once daily [OD] oral and once weekly [OW] subcutaneous [s.c.]) and obesity (OW s.c.) [38,39,40]

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In addition to GLP-1R, the peptide itself appears to be important for this interaction, as the increased levels of GLP-1 after DPP-IV inhibition (with sitagliptin) reduce nicotine consumption in male mice (Tuesta et al., 2017)

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It does not replace nutrition or exercise, but can complement a full wellness plan when levels are low

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