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The phenotypic distinction suggests the ACs have potential utility in supporting the current heart failure classification as an objective measure of heart failure staging but would need further replication and validation

doi: 10.2337/dc20-2975 50 RewersMLudvigssonJ

Pierret, Yuya Mizuno, Pippa Saunders, Eshaya Lim, Riccardo Dr Giorgi, Oliver Howes, Robert McCutcheon, Barbara McGowan, Piya Sen Gupta, Daniel Smith, Khalida Ismail, Toby Pillinger) was published in JAMA Psychiatry

Peripherally administered ghrelin induces bimodal effects on the mesolimbic dopamine system depending on food-consumptive states

Ranasinghe, D

Both have shown meaningful weight loss