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Add poor sleep and elevated stress hormones into the mix, and fat loss becomes even more resistant

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Persistent or unexplained rectal bleeding may require further investigation, including FIT (faecal immunochemical test) testing, in line with NICE guidance (NG12)

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While clinical trials have already established the weight loss benefits of GLP-1s, it is real-world evidence that will show whether these benefits translate into tangible system-level and socioeconomic gains, providing public payers and policymakers with a stronger basis on which to justify reimbursement