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relatively large apparent volume of distribution of ~2-3 L/kg in horse, cows, sheep & dogs reflecting its relatively high lipid solubility in dogs, xylazine is metabolized by the liver to ~20 metabolites, with only 8% eliminated unchanged in the urine, (Rector et al, 1996

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Water content Consequently, Use Karl Fischer titration or a scientifically justified alternative because water affects potency by weight and stability

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