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Kidney Int 2013;83:10106

market by their manufacturers at the request of the Food and Drug Administration (FDA) due to concerns about these drugs possibly damaging heart valves in some users of these medications

It has been shown previously that PTH or PTHrP ligand analogs can distinguish between two high-affinity PTHR1 conformations, R0 and RG, and that efficient binding to R0 results in prolonged signaling responses in cells and prolonged calcemic responses in animals, whereas selective binding to RG results in more transient responses

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The structure of human extracellular copperzinc superoxide dismutase at 1.7 resolution: insights into heparin and collagen binding