Hyperammonemia due to valproic acid in the psychiatric setting
This review explores gut dysbiosis across a broad spectrum of conditions, including neurodegenerative diseases (e.g., AD, PD, ALS), psychiatric disorders (e.g., MDD, BD, PTSD, anxiety), autoimmune syndromes (e.g., MS), and neuroinflammatory or toxic exposures (e.g., radiation, xenobiotics)
Moreover, highly selective small molecule inhibitors of USP14 (IU1 and derivatives), exhibit the capacity to increase the activity of the 26S 15,19 , and show affinities towards USP14 compatible with their use in a chimera design 15,19,20
Keenan K, Hipwell A, McAloon R, Hoffmann A, Mohanty A, Magee K
Involvement of the pro-oncogenic enzyme fatty acid synthase in the hallmarks of cancer: a promising target in anti-cancer therapies
Liew and Mohd-Redzwan, 2018)