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The control HGF without the wash-out step ( black bars 2 ) presented higher indices than the levels of regular control HGF at both HGF doses (also see gray bars 3 with wash-out step)

Acknowledgements This research was supported by the China Postdoctoral Science Foundation in China (2023M740414), the Chongqing Natural Science Foundation in China (CSTB2022NSCQ-MSX1098), the Youth Project of Science and Technology Research Program of Chongqing Education Commission in China (KJQN202201350), and the Tower Foundation Program of Chongqing University of Arts and Sciences in China (R2022YS08)

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Because each organ faces different oxidative pressures, a dose that supports one tissue could, in theory, overshoot another

When administered subcutaneously once weekly, tirzepatide enhances glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying