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2 Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary Allergy, Asthma & Clinical Immunology 2025, 21(Suppl 2) :P-47 Background: Hereditary angioedema (HAE) with C1-inhibitor (C1-INH) deficiency is an autosomal dominant disorder caused by variants in the SERPING1 gene

In theory this is because circulation during exertion was directed to muscles instead of fatty tissues