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[On-screen text: How do GLP-1s work?] Amy Lynn, speaking: The way that this medication works is it simulates this peptide in the body

doi: 10.1002/osp4.342 41 WangGWuPQiuYDongXWangYChiYet al

At 56 weeks, the change in body weight was 8% in the liraglutide group and 2.5% in the placebo group, and 63.2% participants in the liraglutide group achieved weight loss of 5% or greater compared with 27.1% of the placebo groups

They can significantly worsen gas production and sulfur burps

The peak concentration from a weekly injection given on, say, Thursday evening would arrive Friday evening through Saturday

Dosing tiers: Splitting the dose into two administrations (AM and PM) maintains more consistent lipolytic signaling across a 24-hour period