We thank the core imaging facility of Institut Jacques Monod (ImagoSeine facility) for help in image acquisition and processing
Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action
The results of different clinical studies are so far inconclusive and they vary much, depending on experimental design, sample size, health conditions and the chosen rating scale used to asses depressive symptoms in participants
Additionally, GLP-1 RA users had a higher prevalence of psychiatric comorbidity and more often received psychotropics compared with SGLT-2 and DPP-4 inhibitor users (20% in GLP-1 RA users vs 13% in SGLT-2 inhibitor users and 14% in DPP-4 inhibitor users, respectively)
This is achieved by replacing and modifying specific amino acids in human GLP-1
Moreover, GLP-1RAs were reported to inhibit the development of AS in animal models