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Do not use if you have: Allergy to diphenhydramine or other antihistamines COPD or asthma Angleclosure glaucoma Stomach blockage Liver or kidney impairment Urinary retention issues Seizure disorders Thyroid disease Pregnancy or breastfeeding without provider approval How quickly does Benadryl make you sleepy

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Scientific Activity It activates melanocortin G-protein-coupled receptor subtypes in research assays, primarily engaging Gs, adenylyl cyclase, and cyclic AMP signaling

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Matheeussen V, Waumans Y, Martinet W, et al

It does this by helping your body to produce more insulin to lower your blood glucose (sugar) levels