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At the same time, ellagic acid also prevented the decrease of the mitochondrial membrane potential ( Yet another phenolic acid, rosmarinic acid, has been found to reduce the amount of reactive oxygen species and malondialdehyde, which in turn attenuates cellular oxidative stress and protects hydrogen peroxide-treated glial cells (Lee et al., 2008) on SH-SY5Y (human dopaminergic neuron cells) by controlling the upregulation of Bax and the downregulation of Bcl-2, and reduce mitochondrial membrane potential by reducing reactive oxygen species
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CoQ 10 oxidoreductases in the regulation of ferroptosis (1) FSP1 in the regulation of ferroptosis FSP1 as a therapeutic target in cancer FSP1 (formerly AIFM2) was first identified as a ferroptosis regulator among CoQ 10 oxidoreductases through independent unbiased genetic screens conducted by the Conrad and Olzmann groups under conditions of GPX4 inhibition 16,17
