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Acknowledgements All the authors would like to thank the Ensembl platform ( the Cytoscape platform ( and Mingjie Chen (Shanghai NewCore Biotechnology Co., Ltd.) for providing free data analysis and visualization tools ( Ming-Rui Li would like to thank the biliili platform and the fellow netizens ( for their kind help with R coding

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Central mechanisms Stimulation of the acupoint ST36 enhances depolarization of primary afferent C-fibers at peripheral terminals, leading to inhibitory post-synaptic potentials in nociceptive neurons and sustained membrane hyperpolarization

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