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This pivotal finding definitively establishes a Microbial Metabolite (Butyrate) Mitochondrial Carrier (MPC2) Gut Peptide Hormone (GLP-1) causal regulatory axis, unveiling a novel mechanism by which the gut microbiota influences host glucose homeostasis through energy metabolism reprogramming

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It was made available on the NHS for weight loss in 2023, for those with a BMI of 30+

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In major clinical trials, tirzepatide demonstrated a higher efficacy, with patients achieving up to a 22.5% average reduction in body weight