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Short-acting GLP-1RAs primarily lower the post-prandial glucose response by slowing gastric emptying in addition to enhancing insulin secretion ( Shyangdan et al

GLP-1 receptor agonists seem to have the unique ability to reduce these effects without completely blocking dopamine release

Crinecerfont met the primary endpoint with a significant reduction from baseline in the androstenedione level compared to an increase with placebo (-197 ng/dL [-6.9 nmol/L] versus +71 ng/dL [+2.5 nmol/liter], respectively

Clinical eligibility does not translate to real-world access

Discussing your interest in Retatrutide with your current healthcare provider opens the conversation and allows them to document your treatment history and goals

Patients with binge eating disorder who start a GLP-1 should initiate therapy at a low dose and titrate slowly