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Cons: You are limited as to the amount of Testosterone you can administer

GCL is in part regulated by GSH feedback inhibition, thus if GSH is depleted due to oxidative stress, inflammation, or exposure to xenobiotics, de novo synthesis of GSH is upregulated, as is cysteine synthesis

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Even at modest dosages, MTX can cause hepatic fibrosis and cirrhosis as a significant adverse effect

So I decided to try something different this time instead of medications & moisturizers that does seem to help