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There are several hypotheses for the second signal activation and further investigations are necessary in order to find whether is there any common component for all second signals described, for example, the release of ROS 93

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One key process is glutamate excitotoxicity, where a buildup of glutamate at the synapse due to reduced function of the transporter EAAT2 (also known as GLT-1) leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors

I also take other natural brain health supplements (choline, lions mane, ginko & Phosphatidylserine), sleeping better, reduced alcohol intake as well as exercising with stretching and running but have not felt better mentally and emotionally in years

(2) Mix for a few seconds