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According to the fully adjusted model, after the highest tertile was compared with the lowest tertile, the plasma TMAO concentration (OR = 202 (95 % CI 104, 392)

If your body doesnt produce enough intrinsic factors, deficiency can occur

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Nutr Cancer 1995;17:57-75

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Summary: B12 and iron deficiency can cause nail changes including brittleness, spoon-shaped deformities (koilonychia), and occasionally discolouration, due to impaired oxygen delivery and cell division in the nail matrix