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Download the Notable Articles of 2025: nej.md/3L4ot87 In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with early type 2 diabetes
Some users find that morning injections produce fewer sleep disturbances than evening injections
Why the Gut Microbiome Matters in GLP-1 Nausea Did you know that more than 70% of the immune system lives in your gut
Wait 4-6 weeks at the new dose before assessing symptom response
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The GHS-R1a antagonist JMV2959 was shown to reduce alcohol deprivation-mediated increase in alcohol consumption (Suchankova et al., 2013)
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