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In vivo studies using murine and diabetic wound models consistently demonstrate that HAGSH matrices accelerate wound closure, enhance granulation tissue organization, and promote collagen maturation when compared to HA-only or GSH-only counterparts

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Additionally, the MIA-induced model does not require surgery, thereby minimizing infection risks

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Across these studies, researchers consistently observed that GHK-Cu helped skin cells called fibroblasts multiply, which is important because fibroblasts produce collagen and support skin rejuvenation