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In comparison to semaglutide for diabetes, the once-weekly medication dose for weight management must be increased gradually over 16 to 20 weeks from a small starting dose to 2.4 mg

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These differences likely stem from GLP-2s dual action on GLP-1 and GIP receptors, which intensify appetite suppression and caloric expenditure

, Robison L

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Weight loss is a clinically established secondary effect, which is why semaglutide was later studied and approved for chronic weight management under the brand name Wegovy