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Most commonly reported: Nausea (most common, particularly during dose escalation) Diarrhea Vomiting Constipation Abdominal discomfort These effects were generally mild to moderate in severity and tended to diminish as participants adjusted to the treatment, particularly when gradual dose escalation protocols were followed

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[74] found that IL-6 expression was increased while miR-338-5p, a small segment of non-coding RNA, was decreased in patients with DVT, suggesting a negative correlation

Wang Y, Janku F, Piha-Paul S, Hess K, Broaddus R, Liu L, Shi N, Overman M, Kopetz S , Subbiah V, Naing A, Hong D, Tsimberidou AM, Karp D, Yao J, Fu S

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