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A modest increase in resting heart rate was also observed in some participants receiving higher doses, which is an anticipated effect of glucagon receptor agonism and warrants ongoing monitoring in future trials

These effects indicate the medication is working, not that something is wrong

Direct exposure to light, especially UV light, can break down peptide bonds over time

RYGB, Roux-en-Y gastric bypass

Exercise and GLP-1 dynamics present a complex relationship

Moreover, in the SNI-induced chronic neuropathic pain model, heat hyperalgesia was alleviated in mice challenged with SNI and administered intraperitoneal injections of 50 g of exendin 2029, with effects observed as early as 1 hour postadministration and peaking at 2 hours compared with those in the vehicle-administered group (Supplementary Fig