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In contrast to the placebo-treated subjects who experienced minimal changes in body weight over the 16-week treatment period, the pramlintide-treated subjects attained significant weight loss from baseline as early as week 2, which was progressive up to week 16, with no evidence of a plateau

42 The ECL1 was not resolved in the first two structures, and the third map showed that the ECL1 closely interacted with PACAP38 (pituitary adenylate cyclase activating polypeptide-38) without detailed residue contact information due to limited resolution

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Additionally, higher mRNA expression of GLS has been detected in KRAS-mutated non-small cell lung cancer (NSCLC) [93]

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