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The 14-day spacing matches the typical 7-to-14-day window controlled microneedling studies use, and it gives the skin barrier full time to recover between sessions

Biotechnol Adv 36:682690

Depending on the skin color, medium brown skin requires one to three months, and dark skin requires more than two years of treatment

Nature 575:688692 Wei R, Zhao Y, Wang J, Yang X, Li S, Wang Y, Yang X, Fei J et al (2021) Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells