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The two values are comparable both from low-receptor-density cAMP assays (Coskun 2022 explicitly used Willard 2020's method), with a small cross-lab offset (~1.2, gauged from native-ligand controls) so treat the ~16 as a ratio rather than an exact multiple

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Regardless of how and in which way melatonin modulates autophagy, it has been confirmed as a very important and functional protective agent 69