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Akkermansia muciniphila abundance is lower in severe obesity, but its increased level after bariatric surgery is not associated with metabolic health improvement

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Given the clear relationship between IGF-1 and aging, we reasoned that IGF-1R mAbs could provide a translational tool to mimic the beneficial effects reported by reduced signaling in this pathway

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Materials and Methods Animals The in vivo experiments were conducted with 6- to 8-week-old female C57BL/6 mice

Imbalances in this system have been identified as a daily pathological basis for various diseases (176)