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When to seek medical advice: If you experience muscle pain, weakness, or dark urine whilst taking statins (potential signs of myopathy) If severe, persistent abdominal pain occurs whilst on GLP-1 therapy (potential pancreatitis) If cholesterol reduction is not achieved despite treatment adherence Before stopping or changing any prescribed medication If you develop new symptoms or side effects from any therapy Patients should discuss their individual cardiovascular risk profile and treatment options with their GP or specialist

Strains such as Lactobacillus and Bifidobacterium affect immune pathways, and probiotic metabolites, including SCFAs, further contribute to immune regulation (52)

Unlike many peptides that are rapidly degraded in the gut, Dihexas structural modifications allow it to survive digestive enzymes and maintain activity following oral administration in rodent models

Various glycocalyx factors, including SIA, HS, and SDC-1, are crucial in the signal transduction of blood flow shear force, affecting vascular function and related diseases

CB and TC wrote the manuscript