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Primary research: Type 2 diabetes, obesity, metabolic disease Mechanism: Dual activation of GIP and GLP-1 receptors for enhanced metabolic effects Regulatory status: FDA-approved (Mounjaro 2022, Zepbound 2023) Key data: Up to 22.5% weight loss in SURMOUNT trials

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Beyond the microbiome, other metabolic influences such as smoking and alcohol consumption can also impact reproductive function through altered hormone profiles, disrupted oviductal contractility, and impaired endometrial receptivity, further contributing to infertility in endometriosis (43)

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