I look at thyroid
[19] [21] Bupropion has several features that distinguish it from other antidepressants: it does not usually cause sexual dysfunction, [19] it is not associated with weight gain [19] or sleepiness, [22] and it is more effective than SSRIs at improving symptoms of hypersomnia and fatigue
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However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well
It usually means your body is doing a lot of recalibrating behind the scenes
