del Giglio A, Drach J, Novaes M, Dorlhiac-LLacer P, Khetan R, Andreeff M , Chamone DF, Deisseroth A
Weight regain following discontinuation of these medications is common (Figure 2), with up to two-thirds of weight loss being regained within the first year 24
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The implication is striking: these drugs do more than induce weight loss
In therapeutic settings with medical supervision, the medications have benefits including reduced cardiovascular risk
Misfolded -synuclein can be released extracellularly, activating microglia and spreading pathogenic seeds or DAMPs to neighboring neurons, amplifying degeneration