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1 This contrast suggests that duration of supplementation matters substantially

Uridine 5-diphospho-glucuronosyltransferase and Gilberts syndrome Uridine 5-diphospho-glucuronosyltransferase (UGT) catalyses the major metabolic pathway of paracetamol by glucuronidating its phenolic group to form APAP-glu, which is excreted renally [28, 29]

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The reduction of the NADP pool suggests that the electron influx into the NADP pool by metabolism more than compensates for the electron efflux to the antioxidant systems, and that glutathione reductase activity, catalysing the reduction of glutathione from NADPH, is limiting under the specific conditions of reoxygenation after hypoxia