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Animal studies showed developmental risks

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Androgen receptors are expressed by murine and human macrophages, monocytes, neutrophils, T cells, and B cells, in which they exhibit predominantly anti-inflammatory and immunosuppressive effects ( In human monocyte-derived macrophages, murine peritoneal macrophages, and human and murine macrophage cell lines (e.g., RAW 264.7 and J774A.1), testosterone dose-dependently inhibited LPS-induced production of nitric oxide (NO) and TNF, as well as expression of inducible nitric oxide synthase (iNOS/ Nos2 ) and TLR4 (110115)

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H2O2, a necessary evil for cell signaling

The FDA label carries a boxed warning regarding thyroid C-cell tumors observed in rodent studies