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These agents require careful dose titrations due to their adverse drug event (ADE) profile, which commonly includes nausea and vomiting

In parallel, Eli Lilly developed tirzepatide (Mounjaro)--a dual GLP-1 and GIP receptor agonist

Woo JS, Kim W, Ha SJ, Kim JB, Kim SJ, Kim WS, Seon HJ, Kim KS: Cardioprotective effects of exenatide in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of exenatide myocardial protection in revascularization study

Back Eng, J (1993) 'Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same', US Patent 5,424,286

Heres a quick look at some key details about each medication

Am J Physiol Endocrinol Metab 273: E981-988, 1997