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Accessed 22 Jun 2022 Pi-Sunyer X (2014) The Look AHEAD trial: a review and discussion of its outcomes

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Type 2 diabetes is driven by a combination of insulin resistance, reduced insulin production over time, and excess glucose output from the liver

Notably, type 2 diabetes often accelerates kidney function decline even before the onset of AKI, emphasizing the combined influence on CKD development 7,8,9,10

Weight loss from any method can include some lean mass loss, especially if calories are too low or protein and resistance training are inadequate

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