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Diabetes, in particular, type-2 diabetes mellitus (T2DM) is a major public health issue that causes significant morbidity and mortality globally

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Thus, the most accurate interpretation is not safe, but rather no stable teratogenic signal identified to date, with evidence still insufficient for a safety conclusion (132). In clinical counseling, this distinction matters: inadvertent early exposure should generally prompt individualized risk communication and obstetric follow-up, not automatic reassurance and not automatic inference of major harm

However, changes in intestinal microbiota are also described in some extraintestinal diseases, such as type 2 diabetes [19], rheumatoid arthritis [20], systemic lupus erythematosus [21], and other autoimmune diseases